The Biologic Basis For Disease In Adults and Children Discussion
The Biologic Basis For Disease In Adults and Children Discussion
Dermatological Conditions
Psoriasis is an inflammatory disease characterized by an increased epidermal cell turnover rate due to the hyperproliferation of keratinocytes. Clinical manifestations of psoriasis are dependent on the type and location of psoriasis. Patients diagnosed with psoriasis usually present with pruritis, pain, dystrophic nails, long-term rash, scaly redness on the skin, erythematous scaly area, and joint pain (Nair & Badri, 2022). Types of psoriasis include guttate, plaque, pustular, scalp, inverse, conjunctival, nail, psoriatic arthritis, and erythrodermic psoriasis. Treatment of psoriasis includes antimetabolites such as methotrexate, immunomodulators such as cyclosporine, topical corticosteroids such as betamethasone, ophthalmic corticosteroids such as dexamethasone, keratolytic agents such as anthralin, vitamin D analogs, topical retinoids, and injectable corticosteroids The Biologic Basis For Disease In Adults and Children Discussion.
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Lichen planus (LP) is characterized by lesions on the scalp, genitalia, mucous membranes, nails, and flexural surfaces of the limbs such as wrists, which erupt and spread within two to sixteen weeks (Arnold & Krishnamurthy, 2021). Patients experience pruritis and a burning sensation. Clinical manifestations depend on the location and type of LP, such as hypertrophic, atrophic, erosive, follicular, annular, linear, vesicular, bullous, and actinic LP LP is self-limiting within twelve to eighteen months. Treatment is done using topical steroids, systemic steroids, oral metronidazole, cyclosporine, and UVA therapy.
Types of pemphigus include erythematosus, Vulgaris, pemphigoid, foliaceus, and vegetans. Pemphigus erythematosus (PE) is characterized as an overlap of pemphigus foliaceus and lupus erythematosus (Lepe et al., 2021). PE is treated using topical and systemic corticosteroids.
Actinic keratosis (AK) is caused by UV light and can cause invasive squamous cell carcinoma if left untreated. AK begins with small rough lesions that are easily felt and difficult to see. The lesions slowly enlarge to 3 to 10mm and become red and scaly (Marques & Chen, 2022). Treatment depends on the lesions’ number, persistence, history of skin cancer, and patient’s age. Treatment is done using topical 5- fluorouracil, topical diclofenac gel, topical tirbanibulin, imiquimod cream, surgical destruction of lesions, sunscreens, and protective wear from the sun limiting sun exposure.
(There are two discussions, please write one page each.)
Prompt #1
Select one of the following discussion prompts to address:
• Describe the pathophysiology, clinical manifestations, evaluation, and treatment of atopic dermatitis, impetigo contagiosum, tinea capitis, thrush, and molluscum contagiosum.
• Describe the pathophysiology, clinical manifestations, evaluation, and treatment(s) for psoriasis, lichen planus, pemphigus, seborrheic keratosis, and actinic keratosis.
• Describe the incubation periods, the onset of prodromal symptoms, duration, and characteristics of rashes and other clinical symptoms of the following viral diseases: rubella (German measles), rubeola (measles), roseola (exanthema subitum), and varicella (chickenpox). List the CDC-recommended childhood vaccination schedule applicable.
Use at least one scholarly source other than your textbook to connect your response to national guidelines and evidence-based research in support of your ideas The Biologic Basis For Disease In Adults and Children Discussion.
Prompt #2
Select one of the following discussion prompts to address:
• Describe multiple organ dysfunction syndrome (MODS) and summarize the pathophysiology, clinical manifestations, evaluation, and treatment.
• Describe the characteristics of first-, second-, and third-degree burns and the rule of nines assessment tool to estimate burn percentages. Discuss the recommended strategies for initial and maintenance fluid replacement after a major burn injury.
• Summarize the causes, clinical manifestations, evaluation, and treatment for cardiogenic, hypovolemic, neurogenic, anaphylactic, and septic shock.
Use at least one scholarly source other than your textbook to connect your response to national guidelines and evidence-based research in support of your ideas.
Textbook:
Pathophysiology: The Biologic Basis for Disease in Adults and Children
• Author: Kathryn L. McCance and Sue E. Huether
• Publisher: Elsevier
• Edition: 7th (2014)
Read chapters 46-48
References
Arnold DL, Krishnamurthy K. Lichen Planus. [Updated 2022 May 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK526126/
Lepe K, Yarrarapu SNS, Zito PM. Pemphigus foliaceus. [Updated 2021 Nov 15]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK499829/
Marques E, Chen TM. Actinic Keratosis. [Updated 2022 May 9]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK557401/
Nair PA, Badri T. Psoriasis. [Updated 2022 Apr 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK448194/ The Biologic Basis For Disease In Adults and Children Discussion